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KMID : 1038620110290030174
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Radiation Oncology Journal
2011 Volume.29 No. 3 p.174 ~ p.180
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Treatment outcome of nasal natural killer/T-cell lymphoma
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Lee Hyun-Jin
Lee Sang-Wook
Yoon Sang-Min
Kim Young-Seok
Kim Su-San
Kim Jong-Hoon
Choi Eun-Kyung
Ahn Seung-Do
Suh Cheol-Won
Huh Joo-Ryung
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Abstract
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Purpose: To evaluate the radiotherapy treatment outcome of patients in stage IE and IIE nasal natural killer/T-cell lymphoma.
Materials and Methods : From August 1999 to August 2009, 46 patients with stage IE and IIE nasal natural killer/T-cell lymphoma were treated by defi nitive radiotherapy and chemotherapy. 33 patients were treated with chemotherapy followed by radiotherapy (CT + RT) and they received 50.4 Gy in 28 fractions. 13 patients were treated with concurrent chemoradiotherapy (CCRT) and they received 40 Gy in 20 fractions.
Results: The median follow-up period was 4.6-137.6 months (median, 50.2 months) for all patients. The 4-year overall survival was 68.6% and 4-year disease free survival (DFS) was 61.9%. The 4-year locoregional recurrence free survival was 65.0%, and 4-year distant metastasis free survival (DMFS) was 66.2%. For patients treated with CT + RT, 15 patients (45.5%) achieved complete response after chemotherapy, and 13 patients (39.4%) achieved partial response. 13 patients (81.8%) achieved complete response after radiotherapy, and 6 patients (18.2%) achieved partial response. For patients treated with CCRT, 11 patients (84.6%) achieved complete response, and one patient (7.7%) achieved partial response. In univariate analysis, presence of cervical lymph node metastasis was only signifi cant prognostic factor for DFS and DMFS.
Conclusion: This study did not show satisfactory overall survival rate and disease free survival rate of defi nitive radiotherapy and chemotherapy for stage IE and IIE nasal natural killer/T-cell lymphoma. For patients with cervical lymph node metastasis, further investigation of new chemotherapy regimens is necessary to reduce the distant metastasis.
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KEYWORD
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Nasal natural killer/T-cell lymphoma, Radiotherapy, Concurrent chemoradiotherapy
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